Accordingly, elevation of NT-proBNP in the context of non-HF situations should not be regarded as a false-positive finding, and elevated NT-proBNP values should not be discarded without consideration of the serious adverse outcomes associated with the elevation.
10/1/2011 · In this case, the false-positive BNP results were caused by HAMAs interference and had nothing to do with the clinical pathological conditions such as cardiac insufficiency. The clinical doctors should ask the history of animal exposure and consider the possibility of HAMAs interference when the serum BNP level of the patient disagrees with the clinical conditions.
The cause of the false elevated BNP values may be a result of an abnormal immunoassay response with either interfer-encefromheterophilicantibodies,humananti-mouseantibod-ies (stated in the limitations of the AxSYM BNP immunoassay in the package insert), or rheumatoid factors, which can com-monly lead to false results on sandwich-type assays,10,11 as, Clinical Tip: Indiscriminate NT – proBNP testing of all apparently healthy cats should be avoided as the rate of false positive results, and thus normal echocardiograms, is increased in populations with a low prevalence of cardiac disease. However, in this group of cats.
NT-proB-type Natriuretic Peptide (BNP), PBNP – Clinical: NT-Pro B-Type Natriuretic Peptide, Serum, A normal level of NT-proBNP, based on Cleveland Clinic’s Reference Range is: Less than 125 pg/mL for patients aged 0-74 years; Less than 450 pg/mL for patients aged 75-99 years; If you have heart failure, the following NT-proBNP levels could mean your heart function is unstable: Higher than 450 pg/mL for patients under age 50, NT – proBNP values greater than 450 pg/mL are consistent with CHF in adults under 50 years of age. 50-75 years of age: NT – proBNP values below 300 pg/mL have a 99% negative predictive value for excluding acute CHF. A cutoff of 1,200 pg/mL, for patients with an eGFR below 60 yields a diagnostic sensitivity and specificity of 89% and 72% for acute CHF.
Higher-than-normal results suggest that you have some degree of heart failure, and the level of BNP or NT-proBNP in the blood may be related to its severity. Higher levels of BNP or NT-proBNP are often associated with an increased need for aggressive therapy.
